Blar i forfatter "Platz, Elizabeth A."

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    • Circulating free testosterone and risk of aggressive prostate cancer: Prospective and Mendelian randomisation analyses in international consortia 

      Watts, Eleanor L.; Perez-Cornago, Aurora; Fensom, Georgina K.; Smith-Byrne, Karl; Noor, Urwah; Andrews, Colm D.; Gunter, Marc J.; Holmes, Michael V.; Martin, Richard M.; Tsilidis, Konstantinos K.; Albanes, Demetrius; Barricarte, Aurelio; Bueno-de-Mesquita, Bas; Chen, Chu; Cohn, Barbara A.; Dimou, Niki L.; Ferrucci, Luigi; Flicker, Leon; Freedman, Neal D.; Giles, Graham G.; Giovannucci, Edward L.; Goodman, Gary E.; Haiman, Christopher A.; Hankey, Graeme J.; Huang, Jiaqi; Huang, Wen-Yi; Hurwitz, Lauren M.; Kaaks, Rudolf; Knekt, Paul; Kubo, Tatsuhiko; Langseth, Hilde; Laughlin, Gail; Le Marchand, Loic; Luostarinen, Tapio; MacInnis, Robert J.; Mäenpää, Hanna O.; Männistö, Satu; Metter, E. Jeffrey; Mikami, Kazuya; Mucci, Lorelei A.; Olsen, Anja; Ozasa, Kotaro; Palli, Domenico; Penney, Kathryn L.; Platz, Elizabeth A.; Rissanen, Harri; Sawada, Norie; Schenk, Jeannette M.; Stattin, Pär; Tamakoshi, Akiko; Thysell, Elin; Tsai, Chiaojung Jillian; Tsugane, Shoichiro; Vatten, Lars Johan; Weiderpass, Elisabete; Weinstein, Stephanie J.; Wilkens, Lynne R.; Yeap, Bu B.; Allen, Naomi E.; Key, Timothy J.; Travis, Ruth C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-17)
      Previous studies had limited power to assess the associations of testosterone with aggressive disease as a primary endpoint. Further, the association of genetically predicted testosterone with aggressive disease is not known. We investigated the associations of calculated free and measured total testosterone and sex hormone-binding globulin (SHBG) with aggressive, overall and early-onset prostate ...

    • Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis 

      Bouras, Emmanouil; Karhunen, Ville; Gill, Dipender; Huang, Jian; Haycock, Philip C.; Gunter, Marc J.; Johansson, Mattias; Brennan, Paul; Key, Tim; Lewis, Sarah J.; Martin, Richard M.; Murphy, Neil; Platz, Elizabeth A.; Travis, Ruth; Yarmolinsky, James; Zuber, Verena; Martin, Paul; Katsoulis, Michail; Freisling, Heinz; Nøst, Therese Haugdahl; Schulze, Matthias B.; Dossus, Laure; Hung, Rayjean J.; Amos, Christopher I.; Ahola-Olli, Ari; Palaniswamy, Saranya; Männikkö, Minna; Auvinen, Juha; Herzig, Karl-Heinz; Keinänen-Kiukaanniemi, Sirkka; Lehtimäki, Terho; Salomaa, Veikko; Raitakari, Olli; Salmi, Marko; Jalkanen, Sirpa; Jarvelin, Marjo-Riitta; Dehghan, Abbas; Tsilidis, Konstantinos K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-11)
      Background - Epidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due to bias. In order to examine whether altered genetically predicted concentration of circulating cytokines are associated with cancer development, we performed a two-sample Mendelian randomisation (MR) ...